Sold with
the permission of Bristol-Myers Squibb Company
Chemical Name:[3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic
acid
Biological Activity:
Non-prostanoid prostacyclin mimetic that acts as
a partial agonist at IP1 prostacyclin receptors. Potently inhibits
platelet aggregation in vitro (IC50 = 27-35 nM).
Meanwellet al
(1993) Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships
associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid.
J.Med.Chem. 36 3884. Seileret al (1997)
[3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a
potent non-prostanoid prostacyclin partial agonist: effects on platelet
aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost
binding. Prostaglandins 53 21. Rudd et al (2000)
Non-prostanoid prostacyclin mimetics as neuronal stimulants in the rat:
comparison of vagus nerve and NANC innervation of the colon. Br.J.Pharmacol. 129
782.
“I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..”
