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Category:
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Other Activities Sigma and ImidazolineSigma LigandsGeneral Sigma
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Cat.No.
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Product Name
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1440 |
BMY 14802 hydrochloride
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Price and Availability
Click here for full price details of
BMY 14802 hydrochloride
Other Information:
Sold with
the permission of Bristol-Myers Squibb Company
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Chemical Name:
a-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperaz
inebutanol hydrochloride |
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Biological Activity:
Potent sigma receptor antagonist (IC50
= 112 nM) with modest to weak affinity for 5-HT1A and α1
receptors. Antipsychotic following oral administration and acts via indirect
modulation of central dopaminergic systems.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Yevich et al
(1992) Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol
and analogues as potential atypical antipsychotic agents. J.Med.Chem. 35
4516. Zhang et al (1993) Further characterization of the effects
of BMY 14802 on dopamine neuronal activity. Synapse 15 276. Taylor
et al (1993) A role for sigma binding in the antipsychotic profile of
BMY 14802? NIDA Res.Monogr. 133 125.
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or by Research Area
Keywords: BMY 14802 Hydrochloride, Sigma & Imidazoline, Sigma Antagonist. Antipsychotic Agent, BMY14802 Hydrochloride, Tocris Bioscience
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