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Category:
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Enzyme-Linked Receptors Receptor Tyrosine Kinases (RTKs)EGFR
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Cat.No.
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Product Name
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2416 |
BIBX 1382 dihydrochloride
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Price and Availability
Click here for full price details of
BIBX 1382
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Chemical Name:
N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl
)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride |
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Biological Activity:
Potent, selective inhibitor of epidermal growth
factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays >
1000-fold lower potency against Her2 (IC50 = 3.4 μM) and a
range of other related tyrosine kinases (IC50 > 10 μM). Oral
administration inhibits growth of established human xenografts in athymic
mice.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Dittrich et al (2002)
Phase I and pharmacokinetic study of BIBX1382 BS, an epidermal growth factor
receptor (EGFR) inhibitor, given in a continuous daily oral administration.
Eur.J.Cancer 38 1072. Solca et al (2004) Inhibition
of epidermal growth factor receptor activity by two pyrimidopyrimidine
derivatives. J.Pharmacol.Exp.Ther. 311 502.
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or by Research Area
Keywords: BIBX 1382, Receptor Tyrosine Kinases (RTKs), Highly Selective EGFR-kinase Inhibitor, Tocris Bioscience
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Literature in this Area Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
Product Feature
Kinase Inhibitors
Key kinase Inhibitors available from Tocris include:
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