BAM 22P | Opioid Receptors | Opioid Receptor Agonist. Also Agonist At The Sensory Neuron Specific Receptor (SNSR) | Bovine Adrenal Medullary Peptide-22P | BAM 22 (1-22) | BAM22P

Category:

7TM Receptors

Opioid Receptors

Miscellaneous Opioids

Cat.No.

Product Name

1650

BAM 22P

Alternative name(s):	Bovine adrenal medullary peptide-22P
	BAM 22 (1-22)

Price and Availability

Click here for full price details of
BAM 22P

Biological Activity:

Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); isolated from bovine adrenal medulla. EC₅₀ values are 13 and 16 nM for human SNSR3 and SNSR4 respectively. Also potent opioid agonist (IC₅₀ = 1.3 nM in guinea-pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.

Technical Data:

M.Wt:	2839.24
Formula:	C₁₃₀H₁₈₄N₃₈O₃₁S₂
Storage:	Desiccate at -20°C
CAS No:	[76622-26-9]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

For specific/earlier batch please select:

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Mizuno et al (1980) A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem.Biophys.Res.Comm. 97 1283. Lembo et al (2002) Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nature Neurosci. 5 201. Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nature Neurosci. 5 185. Hong et al (2004) Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. 141 423.

View related products by Pharmacological Action or by Research Area

Keywords: BAM 22P, Opioid Receptors, Opioid Receptor Agonist. Also Agonist At The Sensory Neuron Specific Receptor (SNSR), Bovine Adrenal Medullary Peptide-22P, BAM 22 (1-22), BAM22P, Tocris Bioscience

Literature in this Area

Scientific Reviews

Opioid Receptors
Download PDF

Featured New Product

Selective NOP Antagonist

2598 (±)-J 113397

Potent and selective nociceptin / orphanin FQ (NOP, ORL₁) receptor antagonist (IC₅₀ values are 2.3,1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively). Inhibits nociceptin / orphanin FQ-induced hyperalgesia in the mouse tail-flick test.

View all Featured New Products

New Products in this Area

	2965	Diprenorphine
	Non-selective opioid antagonist
	2598	(±)-J 113397
	Potent and selective NOP antagonist
	2601	Cyprodime hydrochloride
	Selective μ antagonist
	2508	Trap 101
	Potent and selective NOP antagonist

for new product e-alerts

User ID
Password