Autocamtide-2-related Inhibitory Peptide | Signal Transduction | Selective CaM Kinase II Inhibitor | AIP

Category:

Cellular Processes and Components

Signal Transduction

Calcium Signalling

Calcium Binding Protein Modulators

Cat.No.

Product Name

1688

Autocamtide-2-related inhibitory peptide

Alternative name(s):

AIP

Autocamtide-2-related inhibitory peptide C64H116N22O19

Price and Availability

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Autocamtide-2-related inhibitory peptide

Biological Activity:

Selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC₅₀ = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC₅₀ > 10 μM).

Technical Data:

M.Wt:	1497.76
Formula:	C₆₄H₁₁₆N₂₂O₁₉
Storage:	Desiccate at -20°C
CAS No:	[167114-91-2]

Resources:

Certificate of Analysis / MSDS:

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References:

Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Comm. 212 806. Ishida and Fujisawa (1995) Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain. J.Biol.Chem. 270 2163. Takasawa et al (1995) Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca²⁺ mobilization. J.Biol.Chem. 270 30257.

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Keywords: Autocamtide-2-related Inhibitory Peptide, Signal Transduction, Selective CaM Kinase II Inhibitor, AIP, Tocris Bioscience

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