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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAgonists
Cat.No. Product Name
0213 D-Aspartic acid  
Price and Availability

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D-Aspartic acid
Chemical Name: D-Aminosuccinic acid

Biological Activity:

Endogenous NMDA receptor agonist with similar activity to the L-isomer (0214). Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.

Technical Data:

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M.Wt: 133.1
Formula: C4H7NO4
Storage: Store at RT
Solubility: Soluble to 100 mM in 1eq. NaOH
CAS No: [1783-96-6]

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    References:

    Olverman et al (1988) Structure/activity relations of NMDA receptor ligands as studied by their inhibition of 3H-D-AP5 binding in rat brain membranes. Neuroscience 26 17. Hashimoto et al (1997) Free D-aspartate and D-serine in the mammalian brain and periphery. Progr.Neurobiol. 53 325. Ishio et al (1998) D-Aspartate modulates melatonin synthesis in rat pinealocytes. Neurosci.Lett. 249 143.
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    Keywords: D-Aspartic Acid, Ligand-gated Ion Channels, NMDA Agonist, DAspartic Acid, Tocris Bioscience
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