Arvanil | Cannabinoid Receptors | Potent CB1 & TRPV1 (VR1) Agonist / Anandamide Transport Inhibitor

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Cat.No.	Product Name
1354	Arvanil

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Arvanil

Chemical Name: N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eic osatetraenamide

Biological Activity:

Cannabinoid CB₁and vanilloid TRPV1 (VR1) agonist (K_i values are 0.5 and 0.3 μM respectively). Also inhibits the anandamide transporter (IC₅₀ = 3.6 μM). Analgesic, vasodilatory and anti-inflammatory in vivo.

Technical Data:

M.Wt:	439.64
Formula:	C₂₈H₄₁NO₃
Storage:	Desiccate at -20°C
Solubility:	Soluble in Ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
CAS No:	[128007-31-8]

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References:

Melck et al (1999) Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 receptors. Biochem.Biophys.Res.Comm. 262 275. Szallasi and Di Marzo (2000) New perspectives on enigmatic vanilloid receptors. TiPS 23 491. Di Marzo et al (2000) Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide. Eur.J.Pharmacol. 406 363.

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Keywords: Arvanil, Cannabinoid Receptors, Potent CB1 & TRPV1 (VR1) Agonist / Anandamide Transport Inhibitor, Tocris Bioscience

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