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Category: EnzymesarrowKinasesarrowCyclin-dependent Kinase
Cat.No. Product Name
2457 Arcyriaflavin A
Price and Availability

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Arcyriaflavin A
Chemical Name: 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5 ,7(6H)-dione

Biological Activity:

Potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM). Also active against CaM kinase II (IC50 = 25 nM) but displays selectivity over several other kinases in vitro (IC50 values for inhibition of PKA and PKC are > 2 and > 100 μM respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM).

Technical Data:

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M.Wt: 325.32
Formula: C20H11N3O2
Storage: Store at -20°C
Solubility: Soluble to 100 mM in DMSO
Purity: >98%
CAS No: [118458-54-1]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Slater et al (1999) Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg.Med.Chem. 7 1067. Zhu et al (2003) Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 1231. Sanchez-Martinez et al (2003) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 3835.
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    Keywords: Arcyriaflavin A, Kinases, Potent Cdk4 / Cyclin D1 & CaM Kinase II Inhibitor. Antiviral Agent (anti-HCMV), Tocris Bioscience
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