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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowPolyamine SitearrowAntagonists
Cat.No. Product Name
0389

Arcaine sulfate  

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Chemical Name: N,N'-1,4-Butanediylbisguanidine sulfate

Biological Activity:

NO synthase inhibitor. An NMDA antagonist acting as a competitive inhibitor at the polyamine site.

Technical Data:

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M.Wt: 270.31
Formula: C6H16N6.H2SO4
Solubility: Soluble to 25 mM in Water
Storage: Store at RT
CAS No: [14923-17-2]

Resources:

Certificate of Analysis / MSDS:

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Product/Material Safety Data Sheet: View current batch
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References:

Reynolds (1990) Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor. Eur.J.Pharmacol. 177 215. Yokoi et al (1994) Structure-activity relationships of arginine analogues on nitric oxide synthase activity in the rat brain. Neuropharmacology 33 1261. Doyle and Shaw (1998) Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 124 386.
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Keywords: Arcaine Sulfate, Ligand-gated Ion Channels, Competitive NMDA Antagonist, Tocris Bioscience
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