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Category:
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7TM Receptors Cannabinoid ReceptorsOther Cannabinoids
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Cat.No.
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Product Name
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1445 |
N-Arachidonylglycine
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| Alternative name(s): |
NAGly |
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Price and Availability
Click here for full price details of
N-Arachidonylglycine
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Chemical Name:
N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)glycine |
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Biological Activity:
Endogenous anandamide-like compound. Lacks
affinity for CB1 receptors (Ki > 10 μM), VR1
receptors (EC50 > 10 μM) and
anandamide transporters (IC50 > 50 μM) but causes
hot-plate analgesia in mice when given orally, and suppresses tonic
inflammatory pain.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Sheskin et al
(1997) Structural requirements for binding of anandamide-type compounds to the
brain cannabinoid receptor. J.Med.Chem. 40 659. Burnstein et
al (2000) Oxidative metabolism of anandamide. Prostaglandins Other Lipid
Mediat. 61 29. Huang et al (2001) Identification of
a new class of molecules, the arachidonyl amino acids, and characterization of
one member that inhibits pain. J.Biol.Chem. 276 42639.
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View related products by Pharmacological Action
or by Research Area
Keywords: N-Arachidonylglycine, Cannabinoid Receptors, Novel Endocannabinoid. Suppresses Pain In Vivo, NAGly, NArachidonylglycine, Tocris Bioscience
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