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Category:
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7TM Receptors Cannabinoid ReceptorsOther Cannabinoids
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Cat.No.
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Product Name
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2836 |
Arachidonyl serotonin
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| Alternative name(s): |
AA-5-HT |
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Price and Availability
Click here for full price details of
Arachidonyl serotonin
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Chemical Name:
N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosate
traenamide |
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Biological Activity:
Dual fatty acid amide hydrolase (FAAH)/TRPV1
blocker (IC50 values are 5.6 and 37-40 nM for FAAH and TRPV1
respectively). Inactive at cPLA2, CB1 or 5-HT receptors.
Displays strong analgesic activity against both acute and chronic peripheral
pain.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Bisogno et al
(1998) Arachidonoylserotonin and other novel inhibitors of fatty acid amide
hydrolase. Biochem.Biophys.Res.Comms. 248 515. Di Marzo et
al (2004) The endocannabinoid system and its therapeutic exploitation.
Nat.Rev.Drug Discov. 3 771. Maione et al (2007)
Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide
hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.
Br.J.Pharmacol. 150 766.
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Keywords: Arachidonyl Serotonin, Cannabinoid Receptors, Dual FAAH / TRPV1 Blocker, AA-5-HT, Tocris Bioscience
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