Apoptosis Activator 2 | Proteases | Promotes Apoptosome Formation & Activates Caspase-9 / Caspase-3 Pathway. Selectively Induces Tumour Cell Apoptosis

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Cat.No.	Product Name
2098	Apoptosis Activator 2

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Apoptosis Activator 2

Chemical Name: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione

Biological Activity:

Apoptosis activator; promotes the cytochrome c-dependent oligomerisation of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumour cells (IC₅₀ = 4-9 μM for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).

Technical Data:

M.Wt:	306.14
Formula:	C₁₅H₉Cl₂NO₂
Storage:	Store at RT
Solubility:	Soluble to 5 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[79183-19-0]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.USA 100 7533.

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Keywords: Apoptosis Activator 2, Proteases, Promotes Apoptosome Formation & Activates Caspase-9 / Caspase-3 Pathway. Selectively Induces Tumour Cell Apoptosis, Tocris Bioscience

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