Chemical Name:(R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinol
ine-10,11-diol hydrochloride
Biological Activity:
Prototypical dopamine agonist (pKi values
are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D1, D2L,
D3, D4 and D5 receptors respectively).
Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian
and neuroprotective actions following systemic administration in vivo.
Liuet al (1996) Low doses of
apomorphine suppress operant motor performance in rats.
Pharmacol.Biochem.Behav. 53 335. Grunblattet al
(1999) Apomorphine protects against MPTP-induced neurotoxicity in mice.
Mov.Disord. 14 612. Millanet al (2002)
Differential actions of antiparkinson agents at multiple classes of
monoaminergic receptor. I. A multivariate analysis of the binding profiles of
14 drugs at 21 native and cloned human receptor subtypes. J.Pharmacol.Exp.Ther.
303 791.
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