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Category: EnzymesarrowKinasesarrowBroad Spectrum Protein Kinase Inhibitors
Cat.No. Product Name
1227 Apigenin
Price and Availability

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Apigenin
Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Biological Activity:

Protein kinase inhibitor. Suppresses tumour-promoting effects of TPA and has antiproliferating effects on human breast cancer cells. Inhibitory actions on MAP kinase also reported.

Technical Data:

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M.Wt: 270.2
Formula: C15H10O5
Storage: Desiccate at +4°C
Solubility: Soluble to 50 mM in DMSO
CAS No: [520-36-5]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Sato et al (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem.Biophys.Res.Comm. 204 578. Kuo and Yang (1995) Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem.Biophys.Res.Comm. 212 767. Lin et al (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J.Cell.Biochem.Suppl. 28-29 39.
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    Keywords: Apigenin, Kinases, Protein Kinase Inhibitor, Tocris Bioscience
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