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Category:
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7TM Receptors Peptides (Gastrointestinal)Apelin Receptors
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Cat.No.
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Product Name
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2427 |
Apelin-36 (rat, mouse)
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Price and Availability
Click here for full price details of
Apelin-36 (rat, mouse)
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Biological Activity:
Endogenous APJ receptor ligand that is secreted
by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4
nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM).
Involved in regulation of cardiovascular function, fluid homeostasis and
feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells
expressing APJ.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Tatemoto et al (1998) Isolation and
characterization of a novel endogenous peptide ligand for the human APJ
receptor. Biochem.Biophys.Res.Comm. 251 471. Zou et al
(2000) Apelin peptides block the entry of human immunodeficiency virus (HIV).
FEBS Lett. 473 15. Kawamata et al (2001) Molecular properties of apelin:
tissue distribution and receptor binding. Biochim.Biophys.Acta 1538
162.
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View related products by Pharmacological Action
or by Research Area
Keywords: Apelin-36 (rat, Mouse), Peptides (Gastrointestinal), Endogenous APJ Receptor Ligand, Tocris Bioscience
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