Apelin-36 (human) | Peptides (Gastrointestinal) | Endogenous APJ Receptor Ligand

Category:

Cat.No.	Product Name
2426	Apelin-36 (human)

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Apelin-36 (human)

Biological Activity:

Endogenous APJ receptor ligand (EC₅₀ = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK-293 cells (pIC₅₀= 8.61). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.

Technical Data:

M.Wt:	4195.87
Formula:	C₁₈₄H₂₉₇N₆₉O₄₃S
Storage:	Desiccate at -20°C
CAS No:	[252642-12-9]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471. Zou et al (2000) Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 473 15. Medhurst et al (2003) Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J.Neurochem. 84 1162.

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Keywords: Apelin-36 (human), Peptides (Gastrointestinal), Endogenous APJ Receptor Ligand, Tocris Bioscience

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