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Category:
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7TM Receptors Peptides (Hypothalamic/Pituitary Hormones)CRF Receptors
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Cat.No.
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Product Name
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2778 |
Antalarmin hydrochloride
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Price and Availability
Click here for full price details of
Antalarmin
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Chemical Name:
N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylpheny
l)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride |
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Biological Activity:
Non-peptide corticotropin-releasing hormone
receptor 1 (CRF1) antagonist (Ki = 1 nM). Suppresses
CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like
behaviour in animal models of anxiety.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Webster et al
(1996) In vivo and in vitro characterization of
antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor
antagonist: suppression of pituitary ACTH release and peripheral inflammation.
Endocrinol. 137 5747. Zorrilla et al (2002) Effects
of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and
motor activation in the rat. Brain Res. 952 188. Specio et
al (2008) CRF1 receptor antagonists attenuate ascalated cocaine
self-administration in rats. Psychopharmacol. 196 473.
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Keywords: Antalarmin, Peptides (Hypothalamic / Pituitary Hormones), CRF1 Antagonist, Tocris Bioscience
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