(±)-Anatoxin A Fumarate | Ligand-gated Ion Channels | Nicotinic Agonist | Anatoxin A Fumarate

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Cat.No.	Product Name
0789	(±)-Anatoxin A fumarate

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(±)-Anatoxin A fumarate

Chemical Name: (±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate

Biological Activity:

A potent nicotinic agonist (K_i values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). Stimulates [³H]-dopamine release from rat striatal synaptosomes (EC₅₀ = 136 nM).

Technical Data:

M.Wt:	281.31
Formula:	C₁₀H₁₅NO.C₄H₄O₄
Storage:	Desiccate at +4°C
Solubility:	Soluble to 50 mM in Water
CAS No:	[64285-06-9]

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Certificate of Analysis / MSDS:

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References:

Stolerman et al (1992) Behavioural effects of anatoxin, a potent nicotinic agonist in rats. Neuropharmacology 31 311. Gordon et al (1992) Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A. J.Pharmacol.Exp.Ther. 263 997. Thomas et al (1993) (+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J.Neurochem. 60 2308. Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal dopamine release. J.Neurosci. 20 2783.

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Keywords: (±)-Anatoxin A Fumarate, Ligand-gated Ion Channels, Nicotinic Agonist, Anatoxin A Fumarate, Tocris Bioscience

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Nicotinic ACh Receptors
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