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Anandamide (in Tocrisolve 100)
Other Information:
Canadian
customers require a CDSA import permit
Chemical Name:N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Biological Activity:
Endogenous cannabinoid and vanilloid
receptor agonist, in water-soluble emulsion (for details see Cat. No.
1684). Ki values are 89 and
371 nM for CB1 and CB2 receptors respectively; pKi
= 5.68 for rVR1. Also blocks TNF-α-induced NF-κB activation via direct
inhibition of IKK. Also available as the
pure oil dissolved in ethanol (Cat. No. 1339).
Pertwee (1999) Pharmacology of cannabinoid receptor ligands.
Curr.Med.Chem. 6 635. Rosset al (2001)
Structure-activity relationship for the endogenous cannabinoid, anandamide, and
certain of its analogues at vanilloid receptors in transfected cells and vas
deferens. Br.J.Pharmacol. 132 631. Gardineret al
(2002) Complex regional dynamic effects of anandamide in conscious rats.
Br.J.Pharmacol. 135 1889. Kagayaet al (2002)
Characterization of the anandamide-induced depolarization of guinea-pig
isolated vagus nerve. Br.J.Pharmacol. 137 39. Sanchoet
al (2003) Anandamide inhibits nuclear factor-κB activation through a
cannabinoid receptor-independent pathway. Mol.Pharmacol. 63 429.
Analogue of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, > 30000 and > 30000 nM for GPR55, CB1 and CB2 receptors respectively). Induces activation of RhoA, cdc42 and rac1.
