Anagrelide | Phosphodiesterases | Potent PDE3 Inhibitor | BL 4162A

Category:

Enzymes

Phosphodiesterases

Cat.No.

Product Name

2432

Anagrelide hydrochloride

Alternative name(s):

BL 4162A

Anagrelide C10H7Cl2N3O.HCl 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride

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Anagrelide

Chemical Name: 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)- one hydrochloride

Biological Activity:

Potent type III phosphodiesterase (PDE3) inhibitor (IC₅₀ = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.

Technical Data:

M.Wt:	292.55
Formula:	C₁₀H₇Cl₂N₃O.HCl
Storage:	Desiccate at +4°C
Solubility:	Soluble to 10 mM in DMSO
Purity:	>99%
CAS No:	[58579-51-4]

Resources:

Certificate of Analysis / MSDS:

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References:

Gillespie (1988) Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity. Biochem.Pharmacol. 37 2866. Mazur et al (1992) Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. Blood 79 1931. Wang et al (2005) Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br.J.Pharmacol. 146 324.

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Keywords: Anagrelide, Phosphodiesterases, Potent PDE3 Inhibitor, BL 4162A, Tocris Bioscience

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