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Category: 7TM Receptorsarrow5-HT Receptorsarrow5-HT2 ReceptorsarrowNon-selective 5-HT2
Cat.No. Product Name
2746 Amperozide hydrochloride
Alternative name(s): FG 5606
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Amperozide
Chemical Name: 4-[4,4-bis(4-Fluorophenyl)butyl]-N-ethyl-1-piperazineca rboxamide hydrochloride

Biological Activity:

Atypical antipsychotic that displays high affinity for 5-HT2 receptors (Ki = 26 nM) and low affinity for D2 receptors Supresses ethanol drinking in genetically ethanol-preferring rats.

Technical Data:

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M.Wt: 437.95
Formula: C23H29F2N3O.HCl
Storage: Store at +4°C
Solubility: Soluble to 50 mM in Water
Purity: >99%
CAS No: [75558-90-6]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Haskins et al (1987) Biochemical and electrophysical studies of the psychotropic compound, amperozide. Brain Res.Bull. 19 465. Meltzer et al (1992) Effect of amperozide on rat cortical 5-HT2 and striatal and limbic dopamine D2 receptor occupancy: implications for antipsychotic action. Eur.J.Pharmacol. 216 67. Myers et al (1993) 5-HT2 receptor blockade by amperozide suppresses ethanol drinking in genetically preferring rats. Pharmacol.Biochem.Behav. 45 741.
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    Keywords: Amperozide, 5-HT Receptors, Atypical Antipsychotic; High Affinity 5-HT2 Ligand, FG 5606, Tocris Bioscience
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