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Category: EnzymesarrowKinasesarrowCyclin-dependent Kinase
Cat.No. Product Name
2072 Aminopurvalanol A
Alternative name(s): NG 97
Price and Availability

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Aminopurvalanol A

Other Information:

Sold under licence from the Regents of the University of California
Chemical Name: (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methyle thyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Biological Activity:

Cell-permeable cyclin-dependent kinase inhibitor. IC50 values are 0.033, 0.033, 0.028 and 0.020 μM for cdk1/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5/p35 respectively. Inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC50 > 100 μM). Arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations > 10 μM.

Technical Data:

 Click here for more information on batch specific data
M.Wt: 403.91
Formula: C19H26ClN7O
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in DMSO
Purity: >98%
CAS No: [220792-57-4]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Chang et al (1999) Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem.Biol. 6 361. Rosiana et al (1999) A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc.Natl.Acad.Sci.USA 96 4797. Knockaert et al (2000) Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chem.Biol. 7 411.
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    Keywords: Aminopurvalanol A, Kinases, Cyclin-dependent Kinase Inhibitor, NG 97, Tocris Bioscience
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