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Aminopotentidine oxalate
Chemical Name:
4-Amino-N-[2-[[(cyanoamino)[[3-[3-(1-piperidinylmethyl)
phenoxy]propyl]imino]methyl]amino]ethyl]benzamide
Biological Activity:
H2 antagonist (KB
values are 220 and 280 nM at human and guinea-pig H2 receptors
respectively) and precursor for the synthesis of the [125I]-iodo
derivative.
Ruat et
al (1990) Reversible and irreversible
labeling and autoradiographic localisation of the cerebral histamine H2
receptor using [125I]iodinated probes. Proc.Natl.Acad.Sci.USA 87
1658. Hirschfield et al (1992) Iodoaminopotentidine and related
compounds: a new class of ligands with high affinity and selectivity for the
histamine H2 receptor. J.Med.Chem. 35 2231. Xieet al
(2006) Synthesis and pharmacological characterization of novel fluorescent
histamine H2-receptor ligands derived from aminopotentidine.
Bioorg.Med.Chem.Lett. 16 3886.
