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Category:
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Ion Channels Sodium ChannelsVoltage-gated Sodium Channels
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Cat.No.
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Product Name
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2404 |
Ambroxol hydrochloride
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Price and Availability
Click here for full price details of
Ambroxol
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Chemical Name:
trans-4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclo
hexanol hydrochloride |
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Biological Activity:
Sodium channel blocker and mucolytic
agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits
tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes
(IC50 values for tonic block are 35.2 and 111.5 μM respectively).
Inhibits release of histamine, leukotrienes and cytokines from human leukocytes
and mast cells.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Gillissen et al (1997)
Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in
vitro. Lung 175 235. Gibbs et al (1999) Ambroxol
inhibits the release of histamine, leukotrienes and cytokines from human
leukocytes and mast cells. Inflamm.Res. 48 86. Weiser and
Wilson (2002) Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive
neuronal Na+ channels by the secretolytic ambroxol. Mol.Pharmacol. 62
433.
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View related products by Pharmacological Action
or by Research Area
Keywords: Ambroxol, Sodium Channels, Na+ Channel Blocker, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
| “Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..” Researcher, University of Aberdeen, UK |
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