Altanserin | 5-HT Receptors | 5-HT2 Receptor Antagonist

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Cat.No.	Product Name
1809	Altanserin hydrochloride

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Altanserin

Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihy dro-2-thioxo-4(1H)-quinazolinone hydrochloride

Biological Activity:

5-HT₂ receptor antagonist. Centrally active following systemic administration in vivo.

Technical Data:

M.Wt:	447.95
Formula:	C₂₂H₂₂FN₃O₂S.HCl
Storage:	Desiccate at +4°C
Solubility:	Soluble to 20 mM in DMSO
Purity:	>98%
CAS No:	[76330-71-7]

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Certificate of Analysis / MSDS:

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References:

Sietnicks (1985) Involvement of 5-HT₂ receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat. J.Neural Transm. 61 65. Koenig et al (1987) Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur.J.Pharmacol. 137 1. Kennett et al (1994) Evidence that 5-HT_2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety. Psychopharmacology 114 90.

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Keywords: Altanserin, 5-HT Receptors, 5-HT2 Receptor Antagonist, Tocris Bioscience

Literature in this Area

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5-HT Receptors & their Ligands
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