Chemical Name:(11a,13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic
acid
Biological Activity:
Prostaglandin with some selectivity for EP3
and EP4 receptors (Ki values are 1.1, 2.1, 36, 10and 33 nM for mouse EP3, EP4,
EP1, EP2 and IP receptors respectively). Inhibits
platelet aggregation and is a vasodilator in vivo.
Whittleet al (1985)
Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin
E1 and D2 on platelets. Adv.Exp.Med.Biol. 192
109. Kirtland (1988) Prostaglandin E1: a review.
Prostaglandins Leukot.Essent.Fatty Acids 32 165. Kiriyamaet
al (1997) Ligand binding specificities of the eight types and subtypes of
the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
Br.J.Pharmacol. 122 217.
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