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Category:
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Nuclear Receptors Retinoic Acid Receptors
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Cat.No.
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Product Name
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2852 |
Adapalene
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| Alternative name(s): |
CD 271 |
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Differin |
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Price and Availability
Click here for full price details of
adapalene
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Chemical Name:
6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-na
phthalenecarboxylic acid |
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Biological Activity:
Retinoic acid analogue that is a RARβ and RARγ agonist (AC50
values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors
respectively). Inhibits proliferation and induces apoptosis in colorectal
cancer cell in vitro. Displays comedolytic activity.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Shroot et al
(1997) Pharmacology and chemistry of adapalene. J.Am.Acad.Dermatol. 36
S96. Millikan (2000) Adapalene: an update on newer comparative studies
between the various retinoids. Int.J.Dermatol. 39 784. Ocker
et al (2003) The synthetic retinoid adapalene inhibits proliferation and
induces apoptosis in colorectal cancer cells in vitro. Int.J.Cancer 107
453.
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Keywords: Adapalene, Retinoic Acid Receptors, RARb & RARg Agonist, CD 271, Differin, Tocris Bioscience
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