Chemical Name:4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-
yl]-5-pentyl-1,3-benzenediol
Biological Activity:
Neurobehaviorally inactive
cannabinoid that acts as a selective agonist for an as-yet unidentified
endothelial receptor for anandamide. Does not bind to CB1 receptors,
yet causes an SR141716A-sensitive vasodilation which is unaffected by blockade
of NOS, COX or vanilloid receptors. Increases phosphorylation of protein
kinases in, and migration of, human umbilical vein endothelial cells.
Jaraiet al (1999) Cannabinoid-induced mesenteric vasodilation
through an endothelial site distinct from CB1 or CB2 receptors.
Proc.Natl.Acad.Sci.USA 96 14136. Ho and Hiley (2003)
Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric
artery. Br.J.Pharmacol. 138 1320. Moet al (2004)
Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled
receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol.
489 21.
Analogue of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, > 30000 and > 30000 nM for GPR55, CB1 and CB2 receptors respectively). Induces activation of RhoA, cdc42 and rac1.
