A 80426 | Adrenergic Receptors | High Affinity A2 Antagonist & 5-HT Uptake Inhibitor | A80426

Category:

Cat.No.	Product Name
2341	A 80426 mesylate

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A 80426

Chemical Name: N-Methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphth alenyl]methyl]-6-benzofuranethanamine mesylate

Biological Activity:

High affinity α₂-adrenoceptor antagonist and selective 5-HT uptake inhibitor (K_i values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.

Technical Data:

M.Wt:	445.57
Formula:	C₂₃H₂₇NO₂.CH₃SO₃H
Storage:	Desiccate at +4°C
Solubility:	Soluble to 10 mM in Water and to 100 mM in DMSO
Purity:	>98%
CAS No:	[152148-63-5]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Meyer et al (1995) Synthesis and pharmacological characterisation of A-80426: a putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition. Bioorg.Med.Chem.Letts. 5 2287. Giardina et al (1995) A-80426, a potent and selective α₂-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile. Drug Devel.Res. 35 246.

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Keywords: A 80426, Adrenergic Receptors, High Affinity A2 Antagonist & 5-HT Uptake Inhibitor, A80426, Tocris Bioscience

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Adrenoceptor Pharmacology
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