A 438079 | Ligand-gated Ion Channels | Competitve P2X7 Antagonist | A438079

Category:

Cat.No.	Product Name
2972	A 438079 hydrochloride

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A 438079

Chemical Name: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyri dine hydrochloride

Biological Activity:

Competitive P2X₇ receptor antagonist (pIC₅₀ = 6.9 for the inhibition of Ca²⁺ influx in the human recombinant P2X₇ cell line). Devoid of activity at other P2 receptors (IC₅₀ >> 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo.

Technical Data:

M.Wt:	342.61
Formula:	C₁₃H₉Cl₂N₅.HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 100 mM in Water
Purity:	>98%
CAS No:	[899507-36-9]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Nelson et al (2006) Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X₇ antagonist. J.Med.Chem. 49 3659. Donnelly-Roberts and Jarvis (2007) Discovery of P2X₇ receptor-selective antagonists offers new insights into P2X₇ receptor function and indicates a role in chronic pain states. Br.J.Pharmacol. 151 571. McGaraughty et al (2007) P2X₇-related modulation of pathological nociception in rats. Neuroscience 146 1817.

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Keywords: A 438079, Ligand-gated Ion Channels, Competitve P2X7 Antagonist, A438079, Tocris Bioscience

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