Selective
PAR4 receptor agonist peptide. Stimulates platelet aggregation in
vitro (EC50 = 15μM). In vivo causes a prompt increase
in paw thickness in the paw oedema inflammation model.
Faruqi et al (2000) Structure-function analysis of
protease-activated receptor 4 tethered ligand peptides. J.Biol.Chem. 275
19728. Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4
(PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived
peptides. Can.J.Physiol.Pharmacol. 79 439. Hollenburg et
al (2004) Proteinase-activated receptor-4: evaluation of tethered
ligand-derived peptides as probes for receptor function and as inflammatory
agonists in vivo. Br.J.Pharmacol. 143 443.
“We always order directly from Tocris since the service is so impeccable. I can only praise the Tocris customer service team who are ready to assist us in every way, without delay. Customer support I receive from other suppliers pales in comparison.”
