Chemical Name:(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate
Biological Activity:
A highly selective and relatively potent group II metabotropic
glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, >
100, > 300 and > 300 μM for human mGlu2,
mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7
receptors respectively. Centrally active following systemic administration in
vivo.
Schoeppet al (1995) Selective inhibition of forskolin-stimulated
cyclic AMP formation in rat hippocampus by a novel mGluR agonist,
2R,4R-4-aminopyrrolidine-2,4-dicarboxylate. Neuropharmacology 34
843. Monnet al (1996) Synthesis of the four isomers of
4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly
selective, and systemically active agonist for metabotropic glutamate receptors
negatively coupled to adenylate cyclase. J.Med.Chem. 39 2990. Schoepp
et al (1999) Pharmacological agents acting at subtypes of
metabotropic glutamate receptors. Neuropharmacology 38 1431.
