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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAntagonists
Cat.No. Product Name
0104

DL-AP7  

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DL-AP7
Chemical Name: DL-2-Amino-7-phosphonoheptanoic acid

Biological Activity:

First generation phosphono NMDA antagonist. Anticonvulsant. See separate isomer (Cat. No. 0164).

Technical Data:

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M.Wt: 225.18
Formula: C7H16NO5P
Storage: Store at RT
Solubility: Soluble to 100 mM in 1eq. NaOH
CAS No: [78966-69-5]

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    References:

    Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. Meldrum and Chapman (1994) Competitive NMDA antagonists as drugs. In The NMDA Receptor (2nd edition). Eds. G. L. Collingridge and J. C. Watkins, p457, Oxford University Press, Oxford, UK.
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    Keywords: DL-AP7, Ligand-gated Ion Channels, Specific NMDA Antagonist, DLAP7, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    The Ins & outs of Glutamate Transporter Pharmacology
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    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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