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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAntagonists
Cat.No. Product Name
0107

L-AP5  

Price and Availability

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L-AP5
Chemical Name: L-(+)-2-Amino-5-phosphonopentanoic acid

Biological Activity:

NMDA antagonist. Also agonist at quisqualate-sensitized AP6 site, where it is more potent than the Δ-isomer (0106).

Technical Data:

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M.Wt: 197.13
Formula: C5H12NO5P
Storage: Store at RT
Solubility: Soluble to 100 mM in 1eq. NaOH and to 100 mM in Water
Purity: >99%
CAS No: [79055-67-7]

Resources:

  • Certificate of Analysis / MSDS:

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    References:

    Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378. Schulte et al (1994) Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203.
    View related products by Pharmacological Action or by Research Area

    Keywords: L-AP5, Ligand-gated Ion Channels, Less Active Form Of DL-AP5 (0105), LAP5, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    The Ins & outs of Glutamate Transporter Pharmacology
    Download PDF
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    Our laboratory loves dealing with Tocris and consider many of the compounds you sell to be far better quality than the compounds that we have received from other companies. Once again, thank you very much..”
    Researcher, Albany Medical College, USA
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