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Category: 7TM ReceptorsarrowGlutamate (Metabotropic) ReceptorsarrowQuisqualate -Sensitised AP6
Cat.No. Product Name
0103

L-AP4  

Price and Availability

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L-AP4
Chemical Name: L-(+)-2-Amino-4-phosphonobutyric acid

Biological Activity:

Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus.

Technical Data:

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M.Wt: 183.1
Formula: C4H10NO5P
Storage: Store at RT
Solubility: Soluble to 5 mM in Water and to 100 mM in 1eq. NaOH
Purity: >99%
CAS No: [23052-81-5]

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    References:

    Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. Nakanishi (1992) Molecular diversity of glutamate receptors and implications for brain functions. Science 258 597. Bushell et al (1995) Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4. Neuropharmacology 34 239. Tones et al (1995) The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain. NeuroReport 7 117.
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    Keywords: L-AP4, Glutamate (Metabotropic) Receptors, Agonist; Also Group III MGlu Agonist, LAP4, Tocris Bioscience
    Literature in this Area
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