DL-AP3 | Glutamate (Metabotropic) Receptors | Group I MGlu Antagonist | DLAP3

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Cat.No.	Product Name
0125	DL-AP3

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DL-AP3

Chemical Name: DL-2-Amino-3-phosphonopropionic acid

Biological Activity:

Competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.

Technical Data:

M.Wt:	169.07
Formula:	C₃H₈NO₅P
Storage:	Store at RT
Solubility:	Soluble to 100 mM in 1eq. NaOH
CAS No:	[20263-06-3]

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References:

Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. Saugstad et al (1995) L-2-Amino-3-phosphonopropionic acid completely antagonizes metabotropic glutamate receptors 1α and 5 in Xenopus oocytes. Eur.J.Pharmacol. 289 395. Hawkinson et al (1996) The metabotropic glutamate receptor antagonist L-2-amino-3-phosphopropionic acid inhibits phosphoserine phosphatase. Eur.J.Pharmacol. 307 219.

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Keywords: DL-AP3, Glutamate (Metabotropic) Receptors, Group I MGlu Antagonist, DLAP3, Tocris Bioscience

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