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cAMPS-Rp, triethylammonium salt
Chemical Name:(R)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate)
triethylammonium
Biological Activity:
Cell-permeable cAMP analogue; acts as a competitive antagonist of
cAMP-induced activation of PKA (IC50 = 11-16 μM) by interacting with cAMP binding sites on the regulatory
subunits. Resistant to hydrolysis by phosphodiesterases.
Van Haastertet al (1984) Competitive cAMP antagonists for
cAMP-receptor proteins. J.Biol.Chem. 259 10020. Rothermel and
Botelho (1988) A mechanistic and kinetic analysis of the interactions of
the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified
cyclic AMP-dependent protein kinase. Biochem.J. 251 757. Dostmannet al (1990) Probing the cyclic nucleotide binding sites of
cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic
phosphorothioates. J.Biol.Chem. 265 10484. Kuriyamaet
al (1995) Isoproterenol inhibits rod outer segment phagocytosis by both
cAMP-dependent and independent pathways. Invest.Ophthalmol.Vis.Sci. 36
730.
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