Chemical Name:8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspir
o[4.5]-decanone
Biological Activity:
Selective 5-HT antagonist, which binds to 5-HT2 sites
as potently as spiperone but has lower affinity for 5-HT2C
receptors. Also a high affinity D2 receptor antagonist (Ki
= 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.
Ismaiel et al (1993) Antagonism of
1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly
identified 5HT2 versus 5HT1C selective antagonist.
J.Med.Chem. 36 2519. Czotyet al (2000) Behavioural
effects of AMI-193, a 5-HT2A- and dopamine D2-receptor
antagonist, in the squirrel monkey. Pharmacol.Biochem.Behav. 67
257.
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