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Category:
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Enzyme-Linked Receptors Receptor Tyrosine Kinases (RTKs)EGFR
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Cat.No.
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Product Name
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0616 |
AG 556
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| Alternative name(s): |
Tyrphostin
AG 556 |
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Price and Availability
Click here for full price details of
AG 556
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Chemical Name:
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2
-propenamide |
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Biological Activity:
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50
= 1.1 μM). Selective over
Her2-neu (IC50 > 500 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted
benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and
ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. Gamett et
al (1997) Secondary dimerization between members of the epidermal growth
factor receptor family. J.Biol.Chem. 272 12052.
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View related products by Pharmacological Action
or by Research Area
Keywords: AG 556, Receptor Tyrosine Kinases (RTKs), EGFR-kinase Inhibitor, Tyrphostin AG 556, AG556, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
Kinase Inhibitors
Key kinase Inhibitors available from Tocris include:
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