AG 18

Alternative name(s):	RG-50810
	Tyrphostin A23

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Chemical Name: [(3,4-Dihydroxyphenyl)methylene]-propenedinitrile

Biological Activity:

Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC₅₀ values are 35 and 25 μM respectively). Inhibits EGF-stimulated cell proliferation.

Technical Data:

M.Wt:	186.17
Formula:	C₁₀H₆N₂O₂
Storage:	Desiccate at +4°C
CAS No:	[118409-57-7]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Gazit et al (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242 933. Gazit et al (1989) Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J.Biol.Chem. 264 14503. Gazit et al (1989) Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344. Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782.

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Keywords: AG 18, Receptor Tyrosine Kinases (RTKs), EGFR/PDGFR-kinase Inhibitor, Tocris Bioscience

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