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Category:
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7TM Receptors Peptides (Hypothalamic/Pituitary Hormones)Gonadotropin-releasing Hormone Receptors
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Cat.No.
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Product Name
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2730 |
AG 045572
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Price and Availability
Click here for full price details of
AG 045572
Other Information:
The prices
shown reflect a special Spring discount of 25% off list price available until
30th June 2008.
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Chemical Name:
5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthale
nyl-methyl]-N-(2,4,6-trimethoxyphenyl)-2-furancarboxami
de |
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Biological Activity:
Selective gonadotropin-releasing hormone (GnRH)
receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse,
rat and human receptors respectively). Suppresses testosterone and luteinising
hormone (LH) levels in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Iatsimirskaia et al
(2002) Effect of testosterone suppression on the pharmacokinetics of a potent
GnRH receptor antagonist. Pharm.Res. 19 202. Anderes et
al (2003) Biological characterization of a novel, orally active small
molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and
intact rats. J.Pharmacol.Exp.Ther. 305 688.
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View related products by Pharmacological Action
or by Research Area
Keywords: AG 045572, Peptides (Hypothalamic / Pituitary Hormones), Selective GnRH Receptor Antagonist, AG045572, Tocris Bioscience
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