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AGN 192403 hydrochloride
Chemical Name:(±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane
hydrochloride
Biological Activity:
I1 imidazoline binding site selective ligand with a
potency at I1 comparable to moxonidine, but devoid of affinity for
adrenoceptors and the I2 binding site. Interestingly, in animal
models, this compound causes none of the physiological responses associated
with the I1 binding site.
Munket
al (1996) Synthesis and pharmacologic evaluation of
2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1
receptor specific agent. J.Med.Chem. 39 1193.
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