AF-DX 384 | Acetylcholine (Muscarinic) Receptors | Potent M2 / M4 Antagonist | AFDX 384

Category:

Cat.No.	Product Name
1345	AF-DX 384

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AF-DX 384

Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5, 6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11 -carboxamide

Biological Activity:

Potent M₂/M₄ selective antagonist (pK_i values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M₂, M₄, M₁, M₃ and M₅ receptors respectively).

Technical Data:

M.Wt:	478.64
Formula:	C₂₇H₃₈N₆O₂
Storage:	Store at RT
Solubility:	Soluble to 50 mM in DMSO and to 10 mM in Ethanol
CAS No:	[118290-27-0]

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Certificate of Analysis / MSDS:

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References:

Dorje et al (1991) Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J.Pharmacol.Exp.Ther. 256 727. Miller et al (1991) Binding of [³H]AF-DX 384 to cloned and native muscarinic receptors. J.Pharmacol.Exp.Ther. 259 601. Dopke et al (1995) AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. J.Pharmacol.Exp.Ther. 274 562.

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Keywords: AF-DX 384, Acetylcholine (Muscarinic) Receptors, Potent M2 / M4 Antagonist, AFDX 384, Tocris Bioscience

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