Chemical Name:(±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid
Biological Activity:
Equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD. Selective
agonist for metabotropic glutamate receptors; active at both group I and group
II mGlu receptors.
Monaghanet al(1989) The excitatory amino acid receptors:
their classes, pharmacology and distinct properties in the function of the
central nervous system. Ann.Rev.Pharmacol.Toxicol. 69 365. Nakanishi
(1992) Molecular diversity of glutamate receptors and implications for
brain functions. Science 258 597. Pin and Duvoisin (1995)
The metabotropic glutamate receptors: structure and functions.
Neuropharmacology 34 1. Knopfelet al (1995)
Metabotropic glutamate receptors: novel targets for drug development.
J.Med.Chem. 38 1417.
Displays 26-fold and > 440-fold selectivity over kainate and NMDA receptors respectively. Neuro-protective; delays neuronal death in a global ischaemia model and cerebral infarction in a focal ischaemia model.
