(1S,3R)-ACPD | Glutamate (Metabotropic) Receptors | Group I/group II MGlu Agonist

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7TM Receptors

Glutamate (Metabotropic) Receptors

Group I mGlu Receptors

Agonists

Cat.No.	Product Name
0284	(1S,3R)-ACPD

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Chemical Name: (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid

Biological Activity:

Active isomer of (±)-trans-ACPD. Active at both group I and II mGlu receptors.

Technical Data:

M.Wt:	173.17
Formula:	C₇H₁₁NO₄
Solubility:	Soluble to 50 mM in Water and to 100 mM in 1eq. NaOH
Purity:	>98 %
Storage:	Store at RT
CAS No:	[111900-32 -4]

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References:

Irving et al (1990) 1S,3R-ACPD stimulates and L-AP3 blocks Ca²⁺ mobilization in rat cerebellar neurons. Eur.J.Pharmacol. 186 363. Pin and Duvoisin (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34 1. Knopfel et al (1995) Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 38 1417. Mistry and Challiss (1996) Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover. Br.J.Pharmacol. 117 1735.

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Keywords: (1S,3R)-ACPD, Glutamate (Metabotropic) Receptors, Group I/group II MGlu Agonist, Tocris Bioscience

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Metabotropic Glutamate Receptors
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The Ins & outs of Glutamate Transporter Pharmacology
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