Chemical Name:N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Biological Activity:
Potent and selective CB1 agonist (Ki = 2.2
nM). Displays 325-fold selectivity over CB2 receptors. Active in
vivo. Also available in water soluble emulsion (Cat. No. 1781).
Hillardet al (1999) Synthesis and characterization of potent and
selective agonists of the neuronal cannabinoid receptor (CB1).
J.Pharmacol.Exp.Ther. 289 1427. Pertwee (1999)
Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6
635. Patelet al (2001) Cannabinoid CB1 receptor
agonists produce cerebellar dysfunction in mice. 2001 Symposium on the
Cannabinoids, International Cannabinoid Research Society.
Highly selective CB2 receptor agonist; Ki values are 0.037 and 363 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.
