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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAgonists
Cat.No. Product Name
0270 trans-ACBD
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trans-ACBD
Chemical Name: trans-1-Aminocyclobutane-1,3-dicarboxylic acid

Biological Activity:

Very potent and selective NMDA agonist. Certain confusion exists over the naming of this compound because of apparent contradictions in the literature. This is the isomer which has the carboyxlic acid and the amino groups on opposite sides of the cyclobutyl ring.

Technical Data:

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M.Wt: 159.14
Formula: C6H9NO4 
Storage: Store at RT
Solubility: Soluble to 100 mM in 1eq. NaOH
CAS No: [117488-23-0]

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    References:

    Lanthorn et al (1990) cis-2,4-Methanoglutamate is a potent and selective NMDA receptor agonist. Eur.J.Pharmacol. 182 397. Allan et al (1990) Synthesis and activity of a potent NMDA agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids. J.Med.Chem. 33 2905.
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    Keywords: trans-ACBD, Ligand-gated Ion Channels, Selective, Very Potent NMDA Agonist, ACBD, Tocris Bioscience
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