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Category:
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Transporters Neurotransmitter TransportersGlutamate Transporters
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Cat.No.
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Product Name
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0271 |
cis-ACBD
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Chemical Name:
cis-1-Aminocyclobutane-1,3-dicarboxylic acid |
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Biological Activity:
Potent, competitive and selective inhibitor of glutamate uptake.
Certain confusion exists over the naming of this compound because
of apparent contradictions in the literature. This is the isomer which has the
carboxylic acid and the amino groups on the same side of the cyclobutyl ring.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Allan et al (1990) Synthesis and activity of a potent NMDA
agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related
phosphonic and carboxylic acids. J.Med.Chem. 33 2905. Fletcher
et al (1991) Inhibition of L-glutamic acid uptake into rat cortical
synaptosomes by the conformationally restricted analogue of glutamic acid, cis-1-aminocyclobutane-1,3-dicarboxylic
acid. Neurosci.Lett. 121 133. Koch et al (1999)
Differentiation of substrate and nonsubstrate inhibitors of the high-affinity,
sodium-dependent glutamate transporters. Mol.Pharmacol. 56 1095.
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or by Research Area
Keywords: cis-ACBD, Neurotransmitter Transporters, Potent, Selective L-glutamate Uptake Inhibitor, Tocris Bioscience
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| “Thank you so much. Tocris’ technical support is the best!.” Researcher, H. Lundbeck A/S, Denmark |
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