AA 2414 | Prostanoid Receptors | Thromboxane A2 (TP) Receptor Antagonist | Seratrodast | AA2414

Category:

7TM Receptors

Prostanoid Receptors

Cat.No.

Product Name

3025

AA 2414

Alternative name(s):

Seratrodast

AA 2414 C22H26O4 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid

Price and Availability

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AA 2414

Chemical Name: 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptan oic acid

Biological Activity:

Thromboxane A₂ (TP) receptor antagonist. Anti-asthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA₂ mimetic in guinea pigs.

Technical Data:

M.Wt:	354.44
Formula:	C₂₂H₂₆O₄
Storage:	Store at +4°C
Solubility:	Soluble to 75 mM in 1.1 eq. NaOH and to 100 mM in DMSO
Purity:	>98%
CAS No:	[112665-43-7]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Ashida et al (1989) A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins 38 91. Kurokawa et al (1994) Antagonism of the human thromboxane A₂ receptor by an anti-asthmatic agent AA-2414. Biol.Pharm.Bull. 17 383. Cui et al (2007) Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers. Eur.J.Pharmacol. 576 99.

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Keywords: AA 2414, Prostanoid Receptors, Thromboxane A2 (TP) Receptor Antagonist, Seratrodast, AA2414, Tocris Bioscience

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