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Category: EnzymesarrowEsterasesarrowPhospholipase
Cat.No. Product Name
1462 AACOCF3
Alternative name(s): Arachidonyl trifluoromethyl ketone
Price and Availability

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AACOCF3
Chemical Name: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one

Biological Activity:

Inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.

Technical Data:

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M.Wt: 356.47
Formula: C21H31F3O
Storage: Desiccate at -20°C
Solubility: Soluble in Ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
CAS No: [149301-79-1]

Resources:

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    References:

    Street et al (1993) Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. Biochemistry 32 5935. Koutek et al (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J.Biol.Chem. 269 22937. Riendeau et al (1994) Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J.Biol.Chem. 269 15619.
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    Keywords: AACOCF3, Esterases, Phospholipase A2 Inhibitor, Arachidonyl Trifluoromethyl Ketone, Tocris Bioscience
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